Ankle effusion requires a choice of medications depending on the cause, such as non-steroidal anti-inflammatory drugs, anti-gout medications, nutritive cartilage medications, and antibiotics. The possible causes of ankle effusion are trauma to the ankle joint, gout, degenerative osteoarthritis, septic arthritis etc. Trauma to the ankle joint can lead to ankle joint effusion, which requires cessation of activity, rest, ice packs in the early stages, and heat packs after 72 hours, as well as the use of non-steroidal anti-inflammatory drugs such as ibuprofen and celecoxib to help reduce the inflammation and swelling of the joint. People with gout can also develop ankle effusion. Anti-gout medications such as colchicine and febuxostat can be applied to help relieve pain, inflammation and joint effusion. Degenerative arthritis resulting in effusion may choose to take oral aminoglucosamine sulfate or intra-articular injections of nutritive cartilage medications such as sodium hyaluronate. Surgery, such as joint fusion, may be needed if medication is not effective. If you suffer from septic arthritis, you need to use antibiotics for anti-infection treatment, such as levofloxacin. Ankle effusion is recommended to go to the hospital in time to improve the relevant examination, clear the cause of the disease to follow the doctor’s instructions for standardized treatment, not blindly apply the above drugs, so as not to cause adverse consequences.