In the clinic, the latest awakening time after craniotomy is not certain, and there may be no way to awaken permanently. Because in the clinic, craniotomy is only a surgical method, the preoperative state is more important, for example, the clinical very common brain hemorrhage, traumatic brain injury and some other diseases, the preoperative state itself is coma, there are many times even if the surgery is performed, basically in the follow-up is very difficult to really wake up. Some are in a long-term vegetative survival state, and some may even cause death after a period of about 1-2 weeks. So it must be judged in the context of the actual situation, and another very important factor is that the head CT must be reviewed in time to observe the changes in the body’s status. There are many factors that may cause coma and affect the time of awakening, and it is important to perfect the examination for a better evaluation.