Because lymphatic tissue is distributed throughout the body, the clinical manifestations of lymphoma are variable depending on the location and extent of the lesion. Primary lesions can be found in lymph nodes, but also in organs other than lymph nodes, such as tonsils, nasopharynx, gastrointestinal tract, spleen, bones and skin, etc. Extra-nodal lesions are particularly common in non-Hodgkin’s lymphoma. Extra nodal lesions are especially common in non-Hodgkin’s lymphoma. The disease metastasizes from the primary site to adjacent lymph nodes in sequence, such as Hodgkin’s disease, and also skips adjacent lymph nodes and spreads to distant lymph nodes, commonly in non-Hodgkin’s lymphoma. 1. Lymph nodes and lymphatic tissues: superficial lymph nodes account for the majority of cases, and HD is more common than NHL in which the most involved lymph nodes are in the neck, followed by the axilla and groin. Lymphadenitis or lymphatic tuberculosis. The deep lymph nodes, most commonly the mediastinal lymph nodes, may compress the superior vena cava and cause superior vena cava syndrome, or they may compress the tracheoesophageal and laryngeal nerves and cause respiratory distress, dysphagia and hoarseness. Malignant lymphomas originating in retroperitoneal lymph nodes are more common than NHL and can cause prolonged, unexplained fever, making clinical diagnosis difficult. Lymphomas that first arise in the pharyngeal lymphatic ring are most often seen in NHL and are often accompanied by subphrenic invasion, with symptoms such as sore throat, foreign body sensation, dyspnea and hoarseness. 2.Extra-nodal onset: Lymphoma can develop in any part of the body except lymphatic tissues, among which gastrointestinal primary is the most common. Lymphoma of stomach and high small intestine can have epigastric pain, vomiting and other symptoms. 3. Systemic symptoms: General weakness, emaciation, loss of appetite, night sweats and irregular fever are often present.