Whether the total bilirubin of 44.4μmol/L is serious or not is related to the patient’s symptoms, the presence or absence of other abnormal indicators and other factors, and cannot be generalized.
The normal value of total bilirubin is 1.71 μmol/L~17.1 μmol/L. Patients with total bilirubin of 44.4 μmol/L are considered to have a mild elevation, which may be caused by physiological factors, or pathologic factors such as liver disease, biliary tract disease, hemolytic disease, and so on.
1. Physiological factors: long-term alcoholism, late night, overwork, strenuous exercise, etc., may cause liver cell damage or increased destruction of red blood cells, resulting in elevated total bilirubin. However, this is usually transient, patients will not have obvious discomfort symptoms, after improving the lifestyle will gradually ease, usually not serious.
2. Pathological factors: Certain liver diseases, such as hepatitis, cirrhosis, liver cancer, etc., will cause certain damage to liver cells, so that their ability to process bilirubin decreases, resulting in elevated total bilirubin. Biliary tract diseases such as gallstones and cholecystitis can affect the excretion of bilirubin, which can also elevate total bilirubin. At this time, patients may also be accompanied by abdominal pain and bloating, loss of appetite, and elevated aminotransferases.
In addition, hemolytic diseases, such as hemolytic anemia, can increase the destruction of red blood cells and the production of bilirubin, which may also lead to an increase in total bilirubin.
Elevated total bilirubin due to physiological factors is generally not serious, but elevated total bilirubin due to pathologic factors is relatively serious, and should be taken seriously, seek medical attention, identify the cause of the disease, and carry out targeted treatment to avoid delaying the condition.