Creatinine 100μmol/L more, if belongs to physiological causes or acute renal failure, after removing the causative factors, symptomatic supportive treatment, generally can be cured; if it is chronic renal failure, generally can not be cured. 1. Physiological causes: generally include strenuous exercise, fever, and eating a lot of meat and other behaviors that cause a large number of metabolites, which may cause an increase in blood creatinine, which is a normal physiological phenomenon, and can be cured through rest or light diet. 2. Acute renal failure: renal failure can be induced by bleeding, heart failure, profuse sweating and acute gastroenteritis, urinary tract obstruction, etc., which can lead to increased blood creatinine. At this time, creatinine increase is mostly acute, and it can be cured by blood transfusion, rehydration and other symptomatic treatment. 3. Chronic renal failure: chronic nephritis, hypertensive nephropathy and lupus nephritis and other renal diseases can also cause chronic kidney damage, resulting in an increase in blood creatinine, creatinine elevation at this time is generally incurable, the principle of treatment is to slow down the progress of the disease. It is suggested that patients with elevated creatinine should consult regular hospitals in time and standardize the treatment under the guidance of physicians.