Transaminase 80U/L is abnormal and is considered to be related to physiological factors such as staying up late, overwork, and liver damage caused by viral hepatitis, drug-induced liver damage, fatty liver, dermatomyositis and other diseases. Normally, the normal value of transaminase is 0~40 U/L. Since transaminase is mainly found in liver cells, when liver cells are damaged, the transaminase in the cells will be released into the bloodstream, which will cause different degrees of elevation of transaminase. High transaminases may be caused by diseases such as viral hepatitis, fatty liver, alcoholic liver, and drug-induced liver damage. If the disease continues to progress, liver failure may manifest. In addition, mild elevation of transaminases can be seen in patients suffering from acute myocardial infarction, dermatomyositis, infectious mononucleosis, and other diseases. Therefore, patients with transaminase 80U/L are advised to go to the hospital for further investigation of the cause of transaminase elevation to avoid delaying their condition.