A creatinine of 213 μmmol/L is considered high. The cause of the disease should be clarified and the severity assessed, such as acute glomerulonephritis, drug-induced renal injury, urinary tract obstruction, heart failure, gastrointestinal bleeding, etc. creatinine elevation is generally not serious; creatinine elevation due to chronic glomerulonephritis is more serious, and active treatment is needed to slow down the progression of the disease. Impaired renal function can be seen in a variety of renal diseases, common as acute glomerulonephritis, drug-induced kidney injury, chronic glomerulonephritis and other diseases, or urinary tract obstruction, heart failure, gastrointestinal bleeding and other conditions. For acute nephritis, symptomatic supportive treatment such as anti-infection (penicillin) and diuresis (furosemide) should be performed; for drug-induced renal injury, drugs causing injury should be discontinued, and hormones (prednisone) should be used in accordance with the doctor’s prescription; and for conditions such as urinary tract obstruction, cardiac failure, and gastrointestinal hemorrhage, treatment modalities such as relief of obstruction, improvement of cardiac function, and transfusion can be performed. In the above cases, creatinine may return to normal, so it is not considered serious. However, chronic glomerulonephritis with elevated creatinine is generally incurable and can progress slowly, and may eventually develop into uremia. Therefore, it is generally more serious and should be taken seriously, and symptomatic treatment should be given in time to slow down the progression of the disease. The above medication should be used in accordance with the doctor’s instructions, and should not be used without authorization. When the creatinine is 213μmmol/L, it is recommended to consult a doctor in a regular hospital in time, make a clear diagnosis, and actively treat the disease.