How much higher than the reference value is normal for alpha-fetoprotein?

The normal value of alpha-fetoprotein is 25 μg/L, above which it is considered high.
Alpha-fetoprotein is a kind of glycoprotein, which is higher in the fetal period and lower in the adult period. Elevated alpha-fetoprotein may be caused by physiological factors, such as newborn, pregnancy, etc., or by pathological factors, such as liver cancer, ovarian cancer, etc.
1. Physiological reasons: newborns and pregnant women will have temporary elevated alpha-fetoprotein, which is physiological phenomenon, no treatment is needed, and it can be slowly recovered to normal value. If alpha-fetoprotein is persistently elevated, it is necessary to identify and investigate neonatal hepatitis and cancer, so as to avoid misdiagnosis and delay in treatment.
2. Pathological causes: for patients with hepatitis and cirrhosis, if the alpha-fetoprotein is more than 400μg/L, they should be alert to primary liver cancer, and can do ultrasound, CT and other further examination.
If high alpha-fetoprotein is caused by cirrhosis, hepatocellular carcinoma, ovarian tumor, etc., it can be treated with medication, such as antiviral drug entecavir, hepatoprotective and enzyme-lowering drug glycyrrhetinic acid preparation, etc., or surgical treatment can also be taken.
High alpha-fetoprotein may be physiological or due to disease. If you have high alpha-fetoprotein, you should consult a doctor in time to clarify the cause of the disease and then cooperate with the doctor for symptomatic treatment.