After drinking alcohol in principle need to be more than a week interval before taking cephalosporins, if you drink alcohol immediately after eating cephalosporins or shorter intervals, it is easy to cause disulfiram-like reaction. The main component of alcohol is ethanol, which can be converted into acetaldehyde and acetic acid in the body, and excreted with urine and breathing. When the human body after drinking alcohol, if immediately or at shorter intervals oral cephalosporins can appear disulfiram-like reaction, mild manifestations of chest tightness, panic, sweating and other symptoms, serious anaphylactic shock can be caused and even life-threatening. Most of the cephalosporins need about a week to be completely metabolized from the body, which is based on the half-life of the drug in the body, so drinking alcohol after a week interval and then oral cephalosporins is safer and more scientific. Drinking alcohol before and after a week should avoid the application of cephalosporins, if there is a misuse of the situation need to go to the hospital immediately for treatment, they can not be randomly used.