Hyperacute rejection usually occurs in xenotransplantation, that is, transplantation between individuals of different species. It is mainly characterized by various immune rejection reactions that occur within 24 hours after the connection between the donor organ and the recipient’s vasculature. This reaction is characterized as acute, rapid and severe, and various anti-immune rejection medications have no significant effect, and can also be common in individuals with repeated blood transfusions, multiple pregnancies and long-term hemodialysis. This is also the cause of hyperacute immune rejection, which is mainly due to blood group compatibility. If a Rh-negative mother has a baby with Rh-positive blood, she will be attacked by the giant number of immune cells in her body during the birth of the second child, and neonatal hemolysis will occur, and in severe cases, the mother will also be attacked.