Factors of low blood manganese include dietary factors (less manganese in food) and disease factors (diabetes mellitus, osteoporosis, etc.). Low blood manganese caused by the above factors can be improved by adjusting the dietary structure to replenish manganese (e.g. consuming more coarse grains, nuts, etc.), and by treating the original disease. 1. Supplement manganese by adjusting dietary structure, e.g. replacing fine cereals with coarse grains in daily diet, eating more nuts and leafy vegetables, etc. Tea is rich in manganese, so manganese can also be supplemented by trace element preparations. 2. Actively treat the primary disease: such as lowering sugar in diabetic patients, supplementing calcium in osteoporosis patients, etc. Low manganese in whole blood is recommended to consult a doctor to clarify the cause of the disease, except for organic lesions, and then correctly treat the disease under the guidance of the doctor.