Ectopic pregnancy HCG drop and then rise again may be drug treatment failure, surgery with residual trophoblast cells and other reasons. 1. Failure of drug treatment: Ectopic pregnancy refers to ectopic pregnancy, when the site of pregnancy is not ruptured, the diameter of the gestational sac <4cm, no obvious internal bleeding, etc., can be given methotrexate medication as prescribed by the doctor, and closely monitor the blood HCG (human chorionic gonadotropin) and ultrasonography, when the HCG falls and then rises again, it means that the treatment has failed, and it is necessary to re-evaluate and formulate a new treatment plan. 2. Surgery with residual trophoblast cells: for those with signs of abdominal bleeding, contraindications to drug treatment or ineffective, etc., surgical treatment is required. When the blood HCG rises again after falling after conservative surgical treatment, there may be residual trophoblast cells, and methotrexate should be given according to the doctor's instructions, and surgery is required again if necessary. Ectopic pregnancy HCG fall and then rise again need to follow the doctor's advice and active management. By the doctor to clarify the diagnosis, and cooperate with the doctor symptomatic treatment.