Submucosal elevation of 2.5 cm may be caused by compression of enlarged spleen and left lobe of the liver, or by gastric smooth muscle tumor, or by gastric mesenchymal stromal tumor. 1. Enlarged spleen, left lobe of the liver compression: enlarged spleen, left lobe of the liver compression can lead to the symptoms of gastric submucosal elevation of 2.5 cm, which is not caused by diseases of gastric mucosa, but by lymphoma, cirrhosis, fatty liver and other diseases. 2. Gastric smooth muscle tumor: Gastric smooth muscle tumor is a kind of benign tumor originated from smooth muscle tissue, which can also lead to the symptoms of gastric submucosal elevation of 2.5 cm, and the patients with large tumors can have the symptoms of hidden pain in the upper abdomen. 3. Gastric Mesenchymal Tumor: Gastric mesenchymal tumor is a kind of benign tumor originated from gastric mesenchymal tissue, which grows slowly, and the patients of this disease will also have the symptom of gastric submucosal elevation of 2.5 centimeters, and in addition, the patients may have the symptoms of epigastric pain, nausea, vomiting and so on. In addition to the above diseases, other diseases can also cause the symptoms of gastric submucosal elevation of 2.5 cm. If this symptom is found in the examination, please follow the doctor’s instructions to complete the relevant examinations to clarify the condition.