Having E. coli in the blood usually causes bacteremia, sepsis, septicemia, etc. Patients are advised to give treatment according to different conditions. 1. Bacteremia: when E. coli is present in the blood and if no growth and reproduction occurs, this may cause bacteremia, and it is recommended that the patient take antibiotic medication under the guidance of a doctor for treatment, such as cefixime, amoxicillin, levofloxacin, etc. 2. Sepsis: When E. coli multiplies in the blood and produces toxins, it may cause sepsis. It is recommended that patients can use drugs such as adenosine deaminase inhibitors, cefazolin, cefotaxime under the guidance of doctors, and if the patients have abscesses, they can be incised and drained, and injected with antimicrobial drugs. 3. Septicemia: If patients are suffering from septicemia, they can choose hemodialysis, extracorporeal membrane lung and other related ways to relieve the treatment under the guidance of doctors. The above mentioned diseases should be treated as soon as possible, and after the condition is under control, patients should follow the doctor’s instructions to go to the hospital regularly for rehabilitation checkups, so as not to affect the recovery situation.