Upper lip suddenly swollen hard, if acute inflammatory infection, need to apply local penicillin ointment or oral anti-inflammatory drugs; angioneurotic edema caused by the need to stop contact with allergens, take anti-allergy drugs. 1. acute inflammatory infection: upper lip suddenly localized swelling and very hard, may be boils carbuncle infection, early touch localized hard lumps, the formation of late abscesses fluctuating sense of touch, can be applied locally penicillin ointment anti-inflammatory, if the formation of abscesses need to be localized incision and drainage, and at the same time, oral antimicrobial drugs such as amoxicillin, metronidazole. 2. Angioneurotic edema: when the lips come into contact with allergens or eat allergic substances, there may be a sudden swelling of the lips, and touched hard, itchy and painful, you need to find the allergens and immediately stop the contact, at the same time, oral anti-allergy drugs such as loratadine. Sudden swelling of the upper lip want to quickly reduce swelling, it is recommended to go to the hospital to check the cause of the targeted treatment, the use of drugs need to follow the doctor’s instructions.