Thickening of liver spots with fatty infiltration means that the patient’s organism is at risk of liver fibrosis, cirrhosis, and fatty liver. Hepatic macular thickening is an image on ultrasound that usually indicates a change in the texture of the patient’s liver, damage to liver cells, and so on. It is often considered to be a precursor to liver fibrosis or cirrhosis. However, liver spot thickening alone does not confirm the diagnosis, and blood tests and liver function tests are needed to make a definitive diagnosis. Fatty infiltration is usually a pathological manifestation of fatty liver, and hepatic fatty infiltration is caused by the presence of fat droplets in liver cells. It is usually an early pathological manifestation of fatty liver formation, which may be caused by the patient’s long-term consumption of high-fat food or heavy alcohol consumption. It is recommended that the patient go to the hospital for further detailed examination to clarify the specific condition, and then follow the doctor’s instructions for treatment.