Bedwetting is what we clinically refer to as enuresis, and its etiology consists mainly of developmental delays and neuropathy. Bedwetting usually refers to the involuntary urination of a child while asleep. In a small number of patients, the symptoms may persist into adulthood. Enuresis is divided into primary enuresis and secondary enuresis. Primary enuresis is defined as enuresis without obvious neurological or urological pathology. Primary enuresis is mainly caused by several etiologies, including delayed cortical development and deeper sleep. Secondary enuresis is mainly due to congenital spina bifida, and neurogenic bladder. In addition to nocturnal enuresis, secondary enuresis may be accompanied by daytime urinary symptoms related to difficulty in urination and frequency of urination. Most enuresis is accompanied by a genetic predisposition, and the patient’s parents and brothers tend to have the same enuresis. Treatment of enuresis begins with clarification of whether the enuresis is primary or secondary, and depending on the cause, the appropriate treatment is chosen. Most children with primary enuresis will resolve themselves by adulthood, and behavioral therapy and medication are equally effective in treating the condition. In summary, the main causes of enuresis include developmental delays and neurological lesions. Primary enuresis often resolves spontaneously but should still be treated with active behavioral therapy.