Treatment of malignant pleural effusion includes systemic treatment and local treatment, as follows: 1. Systemic treatment: to control the primary malignant disease through drugs, including systemic chemotherapy, targeted therapy and new immunotherapy at present; 2. Local treatment: to drain pleural effusion in order to relieve patients’ symptoms of chest constriction and respiratory difficulty, cancer cells can be checked through pleural fluid, which can provide the basis of diagnosis and provide specimens for further testing. Intrathoracic cavity can be injected with some drugs, such as cisplatin, tumor necrosis factor, or adhesive agent of pleura, such as talcum powder, etc. All of these have certain therapeutic effect on lesions on pleura, and at the same time, it can prompt the adhesion of pleural cavity and the atresia of pleural cavity, which can prevent the recurrence of pleural effusion. Therefore, through systemic treatment and local treatment, most patients with pleural effusion can be effectively controlled. Malignant pleural effusion refers to pleural effusion caused by malignant neoplastic diseases, most of the malignant pleural effusion is bloody in nature, caused by malignant tumors metastasized to the pleura or pleural mesothelioma, therefore, once malignant pleural effusion is detected, it means that it is an advanced tumor.