Patients with Hashimoto’s thyroiditis who have rapidly enlarging thyroid glands with localized pain or pressure symptoms may take prednisone to relieve symptoms. There is no treatment for Hashimoto’s thyroiditis that addresses the cause. Limiting iodine intake may help stop the progression of autoimmune destruction of the thyroid. People with goiter only and no hypothyroidism usually do not need treatment. Clinical treatment focuses on symptoms of hypothyroidism and goiter compression. Levothyroxine replacement therapy is given primarily for clinical or subclinical hypothyroidism. Surgery may be considered for those with significant compression symptoms that are not relieved by medication, but the probability of postoperative hypothyroidism is high. Note that the drug is contraindicated in patients with a history of hypersensitivity to prednisone and adrenocorticotropic hormone drugs. Patients with Hashimoto’s thyroiditis should not take medication on their own, but should follow their doctor’s instructions and standardize the use of medication.