The question of when to operate on a child with congenital heart disease is of great concern to parents. Many parents believe that their children are too young to withstand the torment of surgery, and it is safer to wait until the child is older and stronger before performing surgery. Unbeknownst to them, there are many children who have delayed surgery, thus losing the opportunity to have surgery and causing lifelong regrets. With the advanced development of modern medicine, the surgery time for children with congenital heart disease cannot be determined by the age and tolerance of surgery. Of course, the tolerance of surgery is correspondingly poorer in younger children, and the risk of surgery is also greater, but if the heart malformation is complex or the lesion is serious, it can lead to blood circulation disorder and cause damage to cardiopulmonary function. Even if the heart malformation can be corrected later, the damaged heart and lung tissues are difficult to recover, and the successful surgery cannot achieve the purpose of cure. Therefore, the best time for surgery for precordial disease should be determined by the specific condition of the child. The most common precordial arteriovenous ductus arteriosus, ventricular septal defect, atrial septal defect, the operation time depends on the size of the defect, such as large defect, large fractional flow, severe pulmonary congestion, often accompanied by heart failure, pneumonia and other complications, should be operated early, surgery can be performed in infancy (within 1 year). For children with severe cyanotic precordial disease, such as tetralogy of Fallot, pulmonary venous ectopic drainage, and other conditions, surgery should be performed in infancy if there are frequent episodes of hypoxia. If the condition is not very serious, those with cyanosis but does not affect life can be operated after 2 years of age. For serious cardiovascular malformations, such as misalignment of the aorta; permanent arterial trunk, pulmonary artery closure, etc., surgery should be sought as early as possible according to the different conditions of the sick child. In conclusion, a thorough examination should be conducted at a specialized hospital and the best time for surgery should be determined by a pediatric cardiologist according to the condition. For children with less serious conditions who can live a normal life, it is better to operate before school age so as not to hinder the life and learning of the child after school. Of course, the best age for surgery also depends on the objective conditions of surgery, such as medical facilities and the skill level of doctors. Some specialized hospitals with advanced equipment, rich clinical experience and high technology have a high cure rate for infant and child heart surgery, and the results are promising.