With the improvement of people’s living standards, the prevalence of hypertension is increasing year by year, and according to the survey, the number of hypertensive patients in China has reached 160 million, however, there are many types and names of anti-hypertensive drugs in the pharmaceutical market, so how to choose and reasonably use antihypertensive drugs has become a problem for hypertensive patients. In order to help hypertensive patients. The most commonly used diuretics are thiazide diuretics, mainly dihydrocoumaric acid and indapamide, which are suitable for patients with high systolic blood pressure, obesity or cardiac insufficiency, and are used with caution in patients with diabetes mellitus, hyperlipidemia and gout because of the effect of interfering with glucose and lipid metabolism and inducing hyperuricemia. The side effects are interference with glucose and lipid metabolism and induction of hyperuricemia, which are contraindicated in patients with heart block, asthma and peripheral vascular disease. The advantages of these drugs are that they are reliable in lowering blood pressure and do not interfere with glucose and lipid metabolism, especially for elderly patients with hypertension with angina pectoris, peripheral vascular disease, diabetes mellitus, hypertension during pregnancy and combined with renal damage, the commonly used drugs are nifedipine, felodipine, amlodipine, whose Adverse effects are headache, facial flushing and ankle edema due to vasodilatation; 4, angiotensin-converting enzyme inhibitors (ACEI) are clinically indicated for patients with hypertension with left ventricular hypertrophy, cardiac insufficiency, diabetes mellitus and renal insufficiency (creatinine <3mg/L), and the drug has no effect on glucose and lipid metabolism. The side effects are irritant dry cough, hyperkalemia, taste abnormalities and angioneurotic edema, due to the risk of teratogenicity, it is generally not used in pregnant women. 6, alpha-blockers The drug has no effect on blood sugar metabolism and can improve lipid metabolism and prostatic hyperplasia patients with difficult urination symptoms, the clinic is particularly suitable for hypertensive patients with hyperlipidemia and prostatic hypertrophy, the commonly used drugs are prazosin, terazosin and doxazosin, the common side effects are due to the reduction of venous blood return, common are postural hypotension, palpitations and syncope. The goal of blood pressure control in hypertensive patients is 140/90 mmHg in the general population and 130/80 mmHg in patients with diabetes or renal disease. The combined application of antihypertensive drugs has been recognized as a better and reasonable treatment plan, which facilitates the complementary strengths of antihypertensive drugs and reduces or counteracts the adverse effects of certain antihypertensive drugs. It is important to remind the majority of patients that hypertension is one aspect of blood pressure lowering, the important is the protection of target organs (heart, brain, kidney and peripheral blood vessels).