Itching caused by cholestasis is only treated with medication with limited effect, at present, it is necessary to control the primary disease, and then symptomatic treatment. Cholestasis is usually associated with hepatitis, bile duct stones, gallbladder stones cholecystitis and other diseases, you can first take ursodeoxycholic acid, adenosylmethionine, glycyrrhizin and other drugs to control the progress of the disease. 1. Hepatitis: when the liver cells are damaged, it is easy to cause cholestasis, the treatment of this disease requires oral hepatoprotective drugs, such as glycyrrhizic acid glycoside, which mainly utilizes anti-inflammatory and antioxidant mechanisms to restore the liver cells to normal, and after the normalization of the liver function, it can effectively alleviate the itchiness caused by cholestasis. 2. Bile duct stones: If the stones block the bile ducts, resulting in bile ducts not being able to pass, it will cause bile stasis, resulting in itching of the skin. When the stone is removed, ursodeoxycholic acid can be taken orally to promote bile excretion to reduce bilirubin as early as possible, thus relieving itching symptoms. 3. Cholecystitis: When the gallbladder is stimulated by inflammation, it will affect the normal excretion of bile, thus causing cholestasis. If the symptoms are serious, you can take adenosylmethionine as prescribed by the doctor, which can promote adenosylmethionine-dependent lipid membrane phospholipid synthesis, reduce the symptoms of cholestasis, and thus reduce itching. In the cholestasis itchy skin can not blindly use drugs to treat, must be divided into the cause, the specific medication program should be strictly in accordance with the requirements of the doctor.