With the liberalization of the two-child policy, many post-70s and post-80s women are starting to struggle with the issue of whether to have a second child, but in addition to the permission of the policy and the adoption of family meetings, these women also have to think about it, the physical condition. After the age of 35, a woman’s natural fertility begins to decline, and although many women after the age of 40 are still having children, usually, most women lose their fertility completely several years before menopause. Although assisted reproductive technology (ART) can solve the fertility-related problems of many infertile couples, it cannot make up for all families. Women undergoing IVF are too old and have decreased ovarian reserve function, which is the main reason for IVF failure. 1. Women over 35 years of age need to be aware of the fact that their chances of conception are significantly lower than those of the younger age group, and that the fertility of women over 40 years of age is significantly reduced; 2. For women over 40 years of age, doctors are obliged to inform older mothers of the risks of pregnancy, including the relatively high risk of miscarriage and the increased risk of pregnancy complications; 3. Women with diabetes and hypertension, for example, need to be evaluated by an obstetrician and A joint consultation with an obstetrician and internist to assess the risk of pregnancy; 4. If conditions permit, both partners should undergo a comprehensive medical examination that includes a preconception examination. Obstetrics and gynecology should include: gynecologic examination, cervical cytology screening (currently mainly TCT), ultrasound of the uterus and both adnexa. If financial conditions allow, screening for both high-risk HPV virus and TORCH testing is recommended. 5. Take one 0.4mg of folic acid daily starting three months before the planned pregnancy until three months after successful conception. If the pregnancy is unplanned and you do not take folic acid in advance, do not over panic and just start taking it in time. 6. For women with regular menstruation, maintaining a regular sex life (2-3 times/week) from the time of last menstruation can help increase the chance of conception. The 6 days before ovulation is medically defined as the “conception window”, if you can maintain a frequent sex life within these 6 days, you will have the best chance of conception. The risk of delivering a fetus with chromosomal abnormalities/abnormalities increases. Prenatal checkups should be started before the third trimester to give your doctor sufficient time to discuss and provide you with prenatal diagnosis (e.g. NT measurement, or chorionic villus biopsy, Down’s syndrome screening and amniocentesis if necessary for early detection of chromosomal abnormalities). 8. Healthy diet, exercise and a regular routine need not be stressed, whether or not a woman has given birth, but will benefit for life if she can always do so. For example, avoid smoking, excessive alcohol consumption, excessive coffee, drug use, exposure to toxins or harmful chemicals. 9, about the mode of delivery: advanced age is not an absolute indication for cesarean delivery, it is recommended to develop a good lifestyle of healthy diet and regular exercise before pregnancy, and to adhere to exercise during pregnancy, control weight and avoid oversized fetus, if there is no contraindication to vaginal delivery, advanced maternal age can also be delivered; 10, if the first child was delivered by cesarean section, the thickness of the original uterine scar needs to be assessed before pregnancy, such as once the pregnancy is 50-60 days It is important to evaluate the distance between the gestational sac and the scar by ultrasound around 50-60 days of pregnancy.