Drugs such as tinidazole, metronidazole and furazolidone can be substituted for amoxicillin in quadruple therapy. Commonly used drugs in quadruple therapy such as Amoxicillin, Clarithromycin, Omeprazole, Bismuth Potassium Citrate. Amoxicillin belongs to antibiotics, if resistance or allergy to amoxicillin develops, other drugs can be applied instead, such as tinidazole, metronidazole, furazolidone, levofloxacin, tetracycline and so on, and the effect of treatment is the same. If there are conditions, you can do H. pylori culture and drug sensitivity test, testing to choose more sensitive antibiotic treatment. Quadruple therapy for the treatment of H. pylori need to take drugs according to the course of treatment, and one month after stopping the drug and then review to find out whether it is successful in eradicating the disease. It is recommended to standardize the use of medication under the guidance of a physician, do not self-medication.