Mycobacterium marinum has been bad can be taken medication, surgical treatment, physical therapy and other methods to improve the condition, during the treatment should be clear whether the condition has recovered, to avoid the emergence of poor therapeutic effect. 1. Drug treatment: Mycobacterium marineis infection can cause skin papules and nodular damage, if there is no recovery for a long time, you can take drugs for treatment, and the use of drugs is mainly to follow the doctor’s instructions to use antibiotics. Commonly used antibiotic drugs that can treat Mycobacterium marinum are methylphenidate, erythromycin ointment and so on. 2. Surgical treatment: mainly for patients with serious infections and poor improvement after using drugs, surgery is needed to remove the infected tissues. 3. Physical therapy: patients who are not well treated with medication and do not want to undergo surgery can also take liquid nitrogen freezing and infrared irradiation to achieve the effect of clearing up the infection and relieving the rash. Mycobacterium marinum infection has a great relationship with trauma, so the skin should avoid contact with seawater after trauma to reduce the chance of infection. People who work in the ocean should take protective measures.