The thickest meat in the palm of the hand refers to the greater trochanter of the palm, and the causes of pain are considered to be strain, trauma, nerve compression, aseptic inflammation, bacterial or viral infections, and so on. 1. Strain injury: refers to the pain caused by the damage of soft tissues such as the muscles of the pisiform region due to heavy lifting and excessive exercise. 2. Trauma: most commonly seen in pressure injury, hand or wrist fracture, etc., manifested as pain with obvious redness and swelling at the big fissure. 3. Nerve compression: often caused by carpal tunnel syndrome, osteophytes, joint dislocation and cervical spondylosis, etc., mainly manifested as pain at the level of the greater trochanter, numbness, limited movement of the hand and arm, or stiffness of the neck. 4. Aseptic inflammation: including fasciitis, tenosynovitis, osteoarthritis, rheumatoid arthritis, etc. Inflammatory factors stimulate the production of interphalangeal pain, joint swelling, elevated body temperature, and knuckle popping. 5. Bacterial or viral infections: Staphylococcus aureus or herpes zoster virus infections can occur, typically characterized by pain, rash, redness and so on in the palms of the hands at the level of the big fish margins. If there is a wound on the hand, Staphylococcus aureus infection can also cause pus. Pain in the thickest part of the flesh of the palm is more likely, and if the pain persists for a longer period of time, it is recommended to seek medical attention to identify the cause under the guidance of a doctor.