Neuron-specific enolase is one of the tumor marker tests that are used as an adjunct to certain tumors. In addition, dynamic examination to observe its changes is also an indicator of the efficacy of treatment for certain tumors, mainly reflecting markers for lung cancer and neuroendocrine tumors. A slightly elevated neuron-specific enolase does not reflect a neuroendocrine tumor, nor does it reflect lung cancer, but only if it is more than ten times the normal value, it has some reference significance for the above tumors. If the laboratory tests suggest that the neuron-specific enolase is a little bit high, further examination is needed to exclude related tumors according to the patient’s symptoms, such as chest CT and cranial MRI. If there are no symptoms and signs and no abnormalities in the auxiliary examination, the simple high level has no special significance.