Autoimmune liver disease is a chronic liver disease caused after the immune dysfunction in the body, including autoimmune hepatitis, primary biliary cholangitis, primary sclerosing cholangitis and the overlap syndrome caused by their overlap with each other, and its specific treatment is as follows: 1. The current standard protocol for the treatment of autoimmune hepatitis is the use of glucocorticoids alone, or the combination of azathioprine. If patients still cannot achieve therapeutic effect with high-dose glucocorticoids or cannot tolerate high-dose glucocorticoids, cyclosporine A, tacrolimus, budesonide and other drugs can be used as alternative treatment. Patients who cannot tolerate azathioprine can be tried with 6-mercaptopurine or morte-macrolide. 2. For patients with primary biliary cholangitis, ursodeoxycholic acid is the only drug currently recommended. Patients with combined severe pruritus that interferes with daily life can be treated with koleleneamine; 3. For patients with primary sclerosing cholangitis, for which there is no effective treatment, and patients with significant bile duct stricture or cholangitis, endoscopic therapy can be given. The treatment options for different types of autoimmune liver disease vary slightly. Overall, there is no specific treatment for autoimmune liver disease, and symptomatic treatment such as anti-inflammatory, hepatoprotective and biliary therapy is the mainstay. Patients with early detection have a better outcome, while those with late detection have a poorer prognosis, with only liver transplantation available for end-stage patients.