A dry, itchy throat and cough in the middle of the night may be caused by physiological reasons, dry pharyngitis, postnasal drip syndrome, etc. 1. Physiological reasons: if the indoor air is dry, it may cause dryness of the throat, the airway gland secretion is relatively reduced at night, when the mucous membrane of the throat is stimulated, the symptom of dry and itchy throat in the middle of the night, coughing. 2. Dry pharyngitis: some people breathe with their mouths open during the rest period at night, and the dry air will directly enter the respiratory tract, causing dry pharyngitis and symptoms of itchy throat and cough. 3. Postnasal drip syndrome: Inflammation of the nasal cavity and sinuses may result in increased secretion, which flows from the nasopharynx down to the pharynx. Swallowing reflexes are frequent during the day, and mucus backflow is obvious at night after lying down due to the effect of gravity, stimulating the pharynx and causing a dry, itchy throat and cough in the middle of the night. Dry and itchy throat and cough in the middle of the night, should actively go to the hospital for systematic examination and clear diagnosis.