Glioblastoma grade 4 is a very severe form of glioblastoma, and even with aggressive treatment, the average survival time is currently just over a year, and there is no cure. Glioblastoma is the most malignant intracranial tumor and is classified as WHO grade 4. Glioblastoma grows very fast and the prognosis of patients is poor. Glioblastoma is mostly located in the brain parenchyma, most of them grow in the hemispheres of the supratentorial brain, with invasive growth, which will lead to increased intracranial pressure and cerebral edema. Patients usually have severe headache, nausea, vomiting, mental depression, limb weakness, consciousness disorder, speech disorder. At the same time, because of the different brain tissues infiltrated and destroyed by the tumor, there will be corresponding focal deficit symptoms, such as hemiparesis, sensory impairment and aphasia.