Plasma fibrinogen is coagulation factor I, a coagulation factor produced by the liver. Plasma fibrinogen is the final response factor in all coagulation pathways, whether endogenous or exogenous, the final step is the activation of plasma fibrinogen into active fibrin, which is then cross-linked into a fibrin clot to achieve hemostasis. If fibrinogen is low, the body’s coagulation function will be poor, commonly seen in patients with disseminated intravascular coagulation, primary hyperfibrinolysis, severe hepatitis and cirrhosis. Meanwhile, high fibrinogen is common in diabetes mellitus, acute myocardial infarction, rheumatism, acute glomerulonephritis, nephrotic syndrome, burns, multiple myeloma, shock, after major surgery, acute infection, malignant tumors, etc. The concentration of fibrinogen in plasma will be significantly increased.