Degenerative changes in the knee are often due to the age of the elderly with the degeneration of the knee joints, resulting in cartilage damage, can be secondary to the surrounding soft tissue and synovial lesions, can appear joint pain, joint swelling, and impaired mobility of the knee joint. In this case, the following medications can be taken orally: 1) medications that nourish the cartilage, such as glucosamine hydrochloride, glucosamine sulfate, chondroitin sulfate, or oral peptide tablets, 2) anti-inflammatory and pain relief medications, can be taken orally, Meloxicam, Celecoxib, Loxoprofen Sodium tablets, which is very good for relieving the pain in the joints. If secondary synovitis leads to joint swelling and fluid accumulation, you can take oral synovitis tablets for treatment. If there is osteophytes in the joint, it can also be treated with oral anti-osteoplasia tablets or tortoise astragali bone-strengthening granules. Therefore, it is recommended that patients with degenerative changes in the knee joint should be treated at an early stage.