1.Radiological examination: magnetic resonance imaging (MRI), computed tomography (CT) 2.Pathologic diagnosis: from biopsy, fine needle aspiration, biliary brushing. 3, Staging evaluation program includes complete history and physical examination, blood count, liver function tests, chest radiographs, abdominal ultrasound and CT or MRI, retrograde endoscopy or percutaneous hepatic puncture angiography, which may also include ultrasonographic endoscopy, cholangioscopy and laparoscopy. Patients with isolated intrahepatic masses must undergo upper and lower gastrointestinal endoscopy. 4. Staging of gallbladder cancer, intrahepatic cholangiocarcinoma, hepatoportal cholangiocarcinoma and distal cholangiocarcinoma is based on the 2010 TNM system. Hepatic hilar cholangiocarcinoma (Klatskin tumor) is clinically staged according to the Bismuth-Corlette staging of the bile ducts involved.