Cold sweat on the palms and feet is mostly due to the presence of qi deficiency and yang deficiency, which needs to be treated with qi warming and tonifying medications, such as Jin Gui Ren Qi Pills and Pian Zi Li Zhong Pills. Sweating on the palms and feet is a manifestation of sweating in Chinese medicine, which is mainly related to qi deficiency, yin deficiency, and dampness-heat vaporization (dampness-heat evil vaporization of internal organs), etc. Because of the cool sweating, it is not easy to find a solution. Because of the appearance of cool sweat, so, consider not Yin deficiency, damp-heat and other heat evidence, it should be a combination of Qi deficiency and Yang deficiency. For this type of evidence, in order to effectively treat, need to target the choice of warm yang qi tonic drug treatment. Clinically used medicines are Jin Gui Ren Qi Pills and Pian Zi Lizhong Pills, etc. Among them, Jin Gui Ren Qi Pills are good at warming yang and tonifying qi. Among them, Jin Gui Kidney Qi Pill is good for treating sweating associated with kidney yang deficiency and kidney qi deficiency, whereas Radix Rehmanniae Pill is good for treating sweating associated with spleen yang deficiency and qi deficiency. The specific contraindications of the above medicines are not clear, so it is recommended to use the medicines in strict accordance with the doctor’s prescription.