Hidden pain in the epigastric region aggravated by lying down and alleviated by standing up may be caused by peritoneal inflammation, acute gastroenteritis, gastroesophageal reflux disease and other factors, and should be promptly consulted. 1. Inflammation of the peritoneum: bacterial infection, chemical stimulation, physical injury and other factors caused by the inflammatory reaction of the peritoneum, the patient will have vague pain in the epigastric region lying down aggravated by standing up to alleviate the nausea, vomiting, heart rate acceleration, fever, etc., the acute attack should be prohibited from drinking and fasting, and can be prescribed the use of ceftriaxone, metronidazole and other medications for treatment. 2. Acute gastroenteritis: if the patient has a history of unclean diet before the occurrence of the above symptoms, as well as abdominal pain, nausea, vomiting, diarrhea, should be considered to be caused by acute gastroenteritis, such patients should consult a doctor in a timely manner, pay attention to replenish water and electrolytes. 3. Gastroesophageal Reflux Disease (GERD): The above symptoms are caused by the backflow of gastric contents into the esophagus due to the dysfunction of the lower esophageal sphincter, which can be treated with omeprazole, domperidone and other drugs. The above are only some of the common causes. If the symptoms persist, you should consult a doctor for a definitive diagnosis and follow the doctor’s instructions for standardized treatment. The use of drugs must follow the doctor’s instructions, not blindly use their own drugs, in order to avoid adverse consequences.