The main treatments for diffuse thickening of gastric wall which tends to be malignant include surgery, chemotherapy, immunotherapy and so on. 1. Surgical treatment: For early gastric cancer, partial gastrectomy is feasible. If there is no distant metastasis in progressive gastric cancer, radical resection should be performed as far as possible. Surgical resection plus regional lymph node dissection is the main means of treatment for progressive gastric cancer. 2. Chemotherapy: preoperative chemotherapy can shrink the tumor and increase the chance of radical treatment and cure. Postoperative chemotherapy can reduce or avoid postoperative recurrence and metastasis and improve survival rate. 3. Immunotherapy: Immunotherapy is more valued in the comprehensive treatment of gastric cancer, and the drugs include BCG vaccine, Corynebacterium shortum, shiitake mushroom polysaccharides, lymphokine-activated killer cells, cytotoxic T-cells, interleukin-2, interferon and so on. Diffuse thickening of the stomach wall tends to be malignant, it is recommended to follow the doctor’s instructions and actively cooperate with the doctor’s treatment, so as to avoid delaying the condition. All of the above medications should be used under the guidance of a doctor, avoid self-medication.