Clinically, lactulose and cecrops can be used together to relieve symptoms of severe constipation or to prepare the bowel before gastrointestinal surgery. Lactulose is an oral agent that acts as a laxative. When taken, it is broken down by intestinal bacteria and can function to accelerate gastrointestinal motility, soften stools, and promote fecal elimination. Keserol reagent is usually used by enema, the composition of which is divided into glycerol, mannitol or magnesium sulfate, which can play a role in lubricating and softening the stool, and stimulate the contraction of the intestinal wall. However, corkscrew reagents may cause severe anal discomfort when used. The two act on different parts of the body, the action of Kaiser is more limited to lubricate and soften the feces near the anus. Lactulose, on the other hand, can act as a laxative by accelerating the absorption of water from feces in the colon and other large areas of the intestinal tract through osmotic action. Lactulose and Kesler can be used simultaneously to treat severe constipation and for gastrointestinal preparation, but simultaneous use is not recommended for patients with mild constipation, as it can induce severe diarrhea resulting in dehydration, electrolyte disorders, and affecting the patient’s quality of life. Therefore, if patients have diarrhea or need to carry out pre-surgical gastrointestinal preparation, they should use the drug under the guidance of professional doctors and follow the doctor’s instructions. It is forbidden for patients to use the drug on their own to avoid serious adverse reactions.