Surface antigen and surface antibody refer to hepatitis B penta-measurement, and simultaneous positivity may be caused by testing error, hepatitis B recovery and hepatitis B virus subtype infection, which need to be observed and treated with antiviral therapy according to the cause of the disease. 1. Detection error: under normal circumstances, surface antigen and surface antibody will not appear at the same time, and it is often caused by detection error, which needs to re-test the quantitative examination of hepatitis B penta-item, and there is no need for treatment for the time being. 2. Hepatitis B recovery period: when hepatitis B patients are in the stage of recovery, at this time, the virus has not a small amount of residual, while the antibody has begun to gradually produce, there will be surface antigen and surface antibody positive, only need to do regular follow-up examination, after a period of time can return to normal. 3. Hepatitis B virus subtype infection: some patients with hepatitis B virus subtype infection have special condition, they may have positive antibody and antigen at the same time, and need to use entecavir or tenofovir under the instruction of doctor for treatment. Hepatitis B surface antigen and surface antibody positivity suggest complete examination, according to the cause of the disease under the guidance of the doctor for treatment.