If the body is resistant to anesthetics need to know which kind of anesthetics insensitive, in the implementation of anesthesia in the process of anesthesia to increase the dose of anesthetics, but also try to change the method of anesthesia, you can choose to choose the inhalation anesthesia or intrathecal anesthesia. The use of anesthetics need to be injected precisely into the local injection, if the patient’s metabolic rate is large or liver function is relatively strong so that the drug metabolism is relatively fast, you can increase the dosage of anesthetics. When increasing the dosage of general anesthesia for a patient, anesthesia drugs should be used correctly according to body weight, physical condition, surgical method, and age. The emergence of anti-anesthetic physique is the patient’s insensitivity to anesthetic drugs, also called anesthetic drug resistance, mostly patients often drink alcohol or sports athletes, fitness people, this kind of people’s physiological basal metabolic rate is relatively high, the liver and kidney function is relatively strong, usually to the metabolism of anesthetic drug excretion is also faster.