Generally diclofenac sodium may cause an increase in glutamine transaminase because some patients may experience an adverse reaction of liver damage when taking diclofenac sodium. Glutaminase is mainly found in the cell plasma of hepatocytes in the human body, when the liver is damaged, some hepatocytes will be damaged, resulting in rupture of the cell membrane, cell decomposition, the glutaminase present in the cell plasma of hepatocytes will be released into the blood, so that the serum glutaminase is elevated, if the glutaminase continues to be elevated during the use of the medication or remains high, it is recommended that the medication be discontinued for observation. Because diclofenac sodium contains sodium, if the patient is combined with heart failure and other diseases that require sodium restriction, should be taken with caution. Diclofenac sodium may affect prostaglandin synthesis, resulting in renal vasoconstriction, reduced renal blood flow, resulting in renal ischemic injury, therefore, liver and kidney function should be checked regularly when taking diclofenac sodium. Diclofenac sodium may have adverse reactions such as hepatic and renal damage, and should be used under the guidance of a doctor, to avoid blind use of medication to avoid adverse reactions.