Prolonged hepatitis is defined as hepatitis with a disease duration of more than half a year that remains prolonged, and symptoms such as abdominal distension, loss of appetite, and fatigue may occur. Prolonged hepatitis is defined as hepatitis with recurrent liver injury, recurrent and prolonged disease, with a duration of more than six months, with mild abnormalities in symptoms, signs and liver function, and without autoimmune and other systemic manifestations. Patients may experience symptoms such as loss of appetite, abdominal distension, mild fatigue, and pain in the hepatic area, often accompanied by an enlarged liver, and aminotransferases may be continuously or intermittently elevated. Prolonged hepatitis is mainly seen in chronic liver diseases, such as long-term hepatitis B and C viral infections, alcoholic hepatitis, etc. The cause of the disease should be clarified and treatment should be based on the cause. If there is hepatitis B and C virus infection, antiviral drug treatment should be carried out, commonly used drugs include entecavir and tenofovir. When liver function is abnormal, hepatoprotective treatment should be given, and commonly used drugs include diammonium glycyrrhizinate and biphenyl dibenzoate. When suffering from prolonged hepatitis, one should consult a doctor in time, complete the relevant examinations under the guidance of the doctor, identify the cause of the disease and carry out standardized treatment.