The chance of a liver nodule being liver cancer may be 20%, but a comprehensive judgment should also be made based on changes in the nature of the nodule. Liver cancer is usually more likely if the patient has autoimmune liver disease, alcoholic cirrhosis, viral hepatitis, etc., and if the alpha-fetoprotein is significantly elevated during imaging. However, nodules alone are not diagnostic of liver cancer because many liver diseases, such as chronic hepatitis, liver cysts, or cirrhosis, can lead to nodules. In general, only a small number of patients with nodules develop liver cancer. Therefore, patients should not be overly nervous when they find liver nodules. Patients can check whether the alpha-fetoprotein is elevated, and then do a puncture biopsy to analyze the nature of the nodules before proceeding with the relevant treatment. If patients have liver nodules, they should consult a doctor in time and follow the doctor’s instructions to further clarify the diagnosis and treatment, so as to avoid delaying the condition.