1.What is leukocyte spermatozoospermia? The World Health Organization (WHO) stipulates that the number of leukocytes in normal semen should not exceed 1.0×106/ml, and exceeding this value is called leukocytospermia. 2.Does leukocyte spermatozoa affect fertility? The main role of semen leukocytes is to engulf bacteria and foreign bodies. However, an increase in leukocytes can lead to a decrease in sperm concentration, viability and malformation rate, resulting in changes in sperm cell chromatin structure, sperm DNA damage and an increase in the number of immature spermatogenic cells, ultimately causing infertility. 3. What are the main causes of leukocytic spermatozoospermia? Common causes of leukocytosis in semen are: reproductive tract infections, such as common bacteria, chlamydia, mycoplasma and other infections. Reproductive tract infections can involve the male testes, epididymis and other accessory gonads, and the leukocytes and their products in the infected reproductive tract are bound to have an impact on the different stages of sperm development and maturation. Therefore, for high leukocytes caused by infectious factors, anti-inflammatory treatment is needed, and pregnancy can be considered after treatment. 4. How is it treated? Clinically, for patients with leukocyte spermatozoa with inflammatory symptoms, anti-inflammatory or antioxidant treatment can be used to reduce the concentration of leukocytes in semen to improve semen quality and increase the rate of normal sperm morphology, and also to improve sperm motility and male fertility by supplementing with trace elements such as selenium, zinc or vitamin E before conception. 5.Does assisted reproductive technology have any effect? However, in clinical practice, we also encounter the situation where the white blood cells cannot be reduced to normal even after repeated treatment. If this happens, can we have children? For infertile couples undergoing assisted reproduction, high semen leukocytes basically do not affect the process of assisted conception, because we can select high-quality sperm through laboratory semen optimization, which can greatly reduce the impact of semen leukocytes on assisted reproduction technology. For couples who want to have children on their own, further tests are needed to clarify the cause. In addition, we should remind you that while treating high leukocytes, you should stay away from high temperatures, radiation, toxic chemicals and other work environments, quit smoking and limit alcohol, do not stay up late, and exercise appropriately in order to improve the effectiveness of treatment.