Bone metastasis of liver cancer mainly manifests as local bone pain, and as the disease progresses, numbness of limbs, localized lumps and ulceration will gradually appear, etc. Pathological fracture may occur in the middle and late stages, and paraplegia may occur if the nerves of vertebrae are invaded. Bone metastasis of liver cancer usually occurs in the late stage through hematogenous metastasis to the corresponding bone parts, and the corresponding clinical symptoms appear. When bone metastasis of liver cancer occurs, it means that the chance of surgery has been lost. At this time, radiotherapy, chemotherapy and targeted therapy can be considered according to the patient’s condition to alleviate and reduce the symptoms of the patient and prolong the patient’s survival period. When bone metastasis of liver cancer occurs, it is necessary to consult doctor in time and carry out standardized treatment under doctor’s guidance.