Chronic renal failure refers to the chronic failure of the kidney function of the patient, and once this disease occurs, the patient will cause harm to the patient’s health, so you need to know more about the causes of this disease, so as to help prevent it in a timely manner. 1, the hemodynamic changes in the body can cause chronic renal failure, such as shock, depressed heart failure, heart disease and thrombosis, when the patient has these symptoms will lead to a relative lack of blood through the kidneys, the metabolic rate of the patient’s waste will also be a relative decline, and in serious cases will lead to the accumulation of nitrogenous waste. This will cause kidney failure to occur. 2, toxic substances can also cause chronic renal failure, the main reason is that patients often take some drugs that damage the kidneys in their daily lives, when patients take such drugs for a long time will cause considerable damage to the patient’s kidneys, once the kidneys are damaged will lead to the symptoms of renal failure, which will also cause renal failure this disease. This will cause kidney failure. 3, there are also some diseases that can cause chronic renal failure, such as liver failure, bacterial endocarditis, pyelonephritis and lymphosarcoma, etc. When the patient suffers from this disease, it will often cause some damage to the patient’s kidneys, and once the patient’s kidneys are damaged, this will also cause renal failure. It can be seen that many chronic kidney diseases can lead to chronic renal failure, so it is extremely important to actively treat the original disease to prevent or delay the arrival of chronic renal failure. In addition, we have also observed in the clinic that some patients have surfaced the manifestation of chronic renal failure when the kidney disease was discovered, because the medical history is unclear, making it difficult for doctors to presume the cause, this situation is mostly due to chronic nephritis of insidious origin or chronic interstitial nephritis.