Women’s calf swelling may be caused by physiological factors, but also seen in hypoproteinemia, chronic kidney disease, hypothyroidism, lower extremity deep vein valve insufficiency and other factors. It is recommended to consult a doctor in time to clarify the cause of the disease and then treat it. 1. Physiological factors: If standing for a long time, the phenomenon of swollen calves can occur, and if the woman is pregnant, the phenomenon of swollen calves can also occur in the late stage of pregnancy. 2. Hypoproteinemia: the decrease of albumin in the blood due to various factors causes the osmotic pressure to decrease, so that the tissue interstitial space accumulates too much water, which leads to the phenomenon of swelling in the lower limbs. It is recommended to improve the biochemical examination under the guidance of the doctor to clarify the diagnosis, and then supplement protein treatment. 3. Chronic Kidney Disease: Due to the damage of kidney function, the protein content in the urine increases, causing a large amount of loss of albumin in the body, which leads to the symptoms of swelling of the lower legs. At the same time, it is accompanied by swelling of the head and face, reduced urine output and other symptoms, which need to be diagnosed and treated through renal function and urine routine tests. 4. Hypothyroidism: Due to the abnormal function of the thyroid gland, sugar metabolism and fat metabolism are affected, which makes the mucopolysaccharides accumulate under the skin of the calf for a long time, thus causing the symptoms of swelling of the calf. 5. Lower extremity deep vein valve insufficiency: Usually there are deep vein valves in the lower extremity veins of the human body to prevent the backflow of blood, and the valves function abnormally due to various factors. This may lead to blood stagnation in the lower limbs and cause swelling of the calves. If the swelling of the lower legs is difficult to be relieved for a long time, you should consult a doctor in time.