Platelet antibodies refer to the disorder of the body’s immune function, producing autoantibodies against the glycoprotein of platelets, resulting in the destruction of platelets, because the platelet glycoprotein combined with platelet antibodies, after the blood circulation, through the spleen filter, will be recognized by the spleen mononuclear macrophages, and be engulfed, there is a decrease in the number of platelets, if the rate of reduction is greater than the speed of the bone marrow outward release of platelets, the number of platelets in the peripheral blood will become lower and lower, and the patient may have skin and mucous membrane bleeding, nasal and gum bleeding. If the rate of platelet reduction is greater than the rate of platelet release from the bone marrow, the number of platelets in the peripheral blood will be lower and lower, and finally, the number of platelets will be severely reduced, and the patient can have bleeding from the skin mucosa, bleeding from the nose and gums, and even intracranial bleeding in severe cases, which is the pathogenesis of immune thrombocytopenic purpura. Platelet-related antibodies are not only seen in patients with immune thrombocytopenic purpura, but also in other immune diseases, such as systemic lupus erythematosus, rheumatoid arthritis, etc. However, in other immune diseases, the concentration of platelet antibodies is often low.