When it comes to hepatitis, people naturally think of “hepatitis A”, “hepatitis B”, “hepatitis C”, “major and minor triplets “. In fact, in the hepatitis family, there are also alcoholic hepatitis, autoimmune hepatitis, drug-related hepatitis and several other major categories. Among them, the harm is widespread, but people do not pay attention to but the number of people suffering from drug-related hepatitis is not a few. Drugs can relieve people’s pain and restore their health. However, if drugs are misused, they can add to the problem. In the 21st century, there are more than 30,000 types of drugs and health products used by human beings, and with the addition of food additives and environmental pollutants, human beings are living with more than 60,000 chemical substances. In recent years, the number of patients with drug-related hepatitis is increasing and now accounts for 10% of clinical hepatitis patients, and the proportion of patients over 50 years old can exceed 40%, which has seriously threatened people’s life and health. Recently, the Department of Gastroenterology of our hospital admitted three cases of this disease in one day. As we all know, the main metabolism and detoxification site of various drugs entering the body is the liver. If a drug has toxic side effects or the body has an allergic reaction to the drug, the liver will naturally bear the brunt of the damage. Specifically, whether or not liver damage occurs after the use of a drug is related to the liver enzymes in the individual’s body, in addition to the drug itself, so there are some individual differences. The most common drugs that cause drug-related hepatitis include: tetracycline, chloramphenicol, erythromycin, sulfonamides, aspirin, painkillers, pautazone, ibuprofen, cinchofen, rifampin, isoniazid, furantoin, dormant, methyldopa, etc., as well as some antineoplastic drugs, immune preparations and heavy metals such as lead, antimony, bismuth, thallium, etc. There are more than 1000 kinds of drugs in 11 categories. Chinese herbal medicines can also cause drug-related hepatitis. Many people think that herbal medicines are safe and have few toxic side effects, and rarely cause liver damage. However, in recent years, the number of adverse reactions caused by herbal medicines has increased year by year, and the number of cases causing liver damage has also increased year by year. For example, in Xiao Chai Hu Tang, Chai Hu, raw snake bile, and certain ancestral recipes for the treatment of “hepatitis B”. The reason for this is that, in addition to pesticide residues and confusion of species when cultivating herbs, the toxic side effects of the herbs themselves cannot be ignored. There are different types of drug-related liver damage, the common ones are hepatitis type, bile stasis type, simple necrosis type, fatty liver type and mixed type. According to the course of the disease, it can be divided into acute, subacute and chronic, and in severe cases, fulminant liver failure can occur, with sudden massive necrosis of liver cells, and the patient may die within one to two weeks. In terms of age, these two groups are the first victims due to the incomplete development of the drug-metabolizing enzyme system in the liver in infants and children and the failure of the organism in the elderly. The initial symptoms of drug hepatitis may include fever and malaise, followed by poor appetite, nausea and vomiting, liver pain and jaundice, rash or with itching, peripheral blood picture eosinophilia, and laboratory tests of liver function characterized by elevated serum transaminases and alkaline phosphatase. The prevention and treatment of drug hepatitis should do the following four things: 1. Drugs should be carefully selected before use, and it is advisable to be few and precise. Combined use of drugs, should be alert to the metabolites between drugs, the formation of new hepatotoxic substances. 2, medication should be used to avoid unfavorable conditions. Such as fasting or starvation, nutritional deficiency, and taking drugs after alcoholism or intoxication. Avoid taking barbiturate or dormantine drugs together or isoniazid and reserpine together. The toxicity of drugs to the liver increases in people over 55 years of age, and caution should be exercised in patients with liver disease and those with abnormal liver function. 3, the use of drug metabolism of each other to prevent liver damage. Cysteine can reduce the toxicity of paracetamol, para-aminosalicylic acid can reduce or prevent the liver damage of isoniazid, corticosteroids can prevent most drug-related liver damage, and sulfur hydrogen-based drugs can prevent drug-related liver damage. 4. Early diagnosis and immediate drug discontinuation are the most effective treatments for drug-related hepatitis. In addition, quiet rest, strengthen nutrition, supplement high protein, high sugar and low fat, vitamins and various amino acids are conducive to drug excretion. For patients with severe disease, they should be hospitalized immediately and comprehensive measures should be taken, such as glutathione, hormones, biliary amines and dialysis therapy, etc. Systematic treatment should be given to alleviate the progress of the disease.