After systemic metastasis of lung cancer in advanced stage, one still needs to actively cooperate with doctors for treatment, which can improve symptoms and prolong survival period after active treatment. Lung cancer is a malignant tumor of respiratory system caused by heredity, smoking and other factors. When the disease develops into advanced stage, multiple distant metastases, such as brain metastasis, liver metastasis, bone metastasis and so on, can occur. During this period, patients can still be treated with various therapies such as surgery, radiotherapy, targeted therapy and immunotherapy according to their conditions. After active treatment, patients’ quality of life can be improved and their survival time can be prolonged. Patients and their families should face the disease with optimism and actively cooperate with doctors.