Large pimples on the nose are usually caused by acne. Commonly used topical medications include retinoids and antibacterial creams, etc. It is recommended to use them correctly under the guidance of a doctor. 1. Vitamin A creams: such as adapalene gel, tazarotene gel, etc. These drugs help dissolve and discharge acne, and also improve and prevent hyperpigmentation, but are contraindicated for those who are allergic to this product. In addition, the use of such drugs may also appear dry, scaly and local discomfort and other adverse reactions. 2. Antibacterial ointment: common drugs are benzoyl peroxide, erythromycin or clindamycin ointment, etc., can be seen in the development of acne to the later stages of bacterial infection when applied, to note that allergic to the drug is prohibited. In addition, the use of such drugs may also appear local skin burning sensation, redness and other adverse reactions. Therefore, it is recommended to go to the hospital in time to avoid delaying the condition of the nose acne.